{"id":73088,"date":"2018-09-05T11:53:24","date_gmt":"2018-09-05T09:53:24","guid":{"rendered":"http:\/\/rades.2d-mediadesign.com\/about-rades\/publications\/"},"modified":"2026-01-15T13:57:13","modified_gmt":"2026-01-15T12:57:13","slug":"publications","status":"publish","type":"page","link":"https:\/\/rades-development.com\/en\/about-rades\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243;][vc_column column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; zoom_width=&#8221;0&#8243; zoom_height=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_column_text el_class=&#8221;rades-main-headline&#8221;]<\/p>\n<div class=\"rades-main-headline-icon\"><img decoding=\"async\" src=\"https:\/\/rades-development.com\/wordpress\/wp-content\/uploads\/2018\/01\/rades-icon-1.png\" \/><\/div>\n<div class=\"rades-main-headline-content\"><span class=\"rades-main-headline-text\">Publications<\/span><\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;3&#8243; back_color=&#8221;color-375106&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243;][vc_column column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; zoom_width=&#8221;0&#8243; zoom_height=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-publications-row-first&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_column_text el_class=&#8221;rades-main-headline&#8221;]<\/p>\n<div class=\"rades-smaller-headline-icon\"><img decoding=\"async\" src=\"https:\/\/rades-development.com\/wordpress\/wp-content\/uploads\/2018\/01\/rades-icon-column-3.png\" \/><\/div>\n<div class=\"rades-smaller-headline-content\"><span class=\"rades-smaller-headline-text\">List of publications in journals<\/span><\/div>\n<p>[\/vc_column_text][vc_column_text uncode_shortcode_id=&#8221;268779&#8243;]<\/p>\n<ul>\n<li>Lunter D, <b>Gorissen S, Herbig ME,<\/b> Hukauf M, Eichner A, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0939641125003492\" target=\"_blank\" rel=\"noopener\">Reflection paper on the APV workshop on in vitro performance testing of topically applied and topically acting substances<\/a>, Eur J Pharm Biopharm (220), 2026, 114971<\/li>\n<li>Surber C, <b>Herbig ME<\/b>, Reinau-H\u00e4berlin D, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022354925005635\" target=\"_blank\" rel=\"noopener\">The Crux of vehicle designations: The essence of topical dermatologic vehicles and their use<\/a>, <span lang=\"DE\">Journal of Pharmaceutical Sciences, 2025, 104109<\/span><\/li>\n<li><b class=\"sh-color-black sh-color\">Evers DH, Giebel J, Nienau F,<\/b> Carle S, <b class=\"sh-color-black sh-color\">Gorissen S<\/b>, Buske J, <b class=\"sh-color-black sh-color\">Herbig ME<\/b>, Garidel P, <b class=\"sh-color-black sh-color\">Hagelskamp E<\/b>, <a href=\"https:\/\/doi.org\/10.1016\/j.ejpb.2025.114854\" target=\"_blank\" rel=\"noopener\">Unravelling the polysorbate 20 composition: A fusion of UPLC-MS analysis and stochastic modelling<\/a>, Eur J Pharm Biopharm (216), 114854, 2025<\/li>\n<li><span class=\"sh-color-black sh-color\" lang=\"EN-US\">Schoenfelder H, Reuter M<b class=\"sh-color-black sh-color\">, Evers D, Herbig ME<\/b>, Lunter DJ, <a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.molpharmaceut.4c01245\" target=\"_blank\" rel=\"noopener\">Ceramide Profiling of Porcine Skin and Systematic Investigation of the Impact of Sorbitan Esters (SEs) on the Barrier Function of the Skin<\/a>. <\/span><i class=\"sh-color-black sh-color\">Molecular Pharmaceutics<\/i>, <i class=\"sh-color-black sh-color\">22<\/i>\u00a0(4), 2019-2028, 2025<\/li>\n<li>Hsiao W-K, <b class=\"sh-color-black sh-color\">Herbig ME<\/b>, Newsam JM, Gottwald U, May E, Winckle G, Birngruber T. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0928098724002264\" target=\"_blank\" rel=\"noopener\">Opportunities of topical drug products in a changing dermatological landscape<\/a>. European Journal of Pharmaceutical Sciences, Volume 203, 106913, 2024<\/li>\n<li>Carle S, <b class=\"sh-color-black sh-color\">Evers DH, Hagelskamp E<\/b>, Garidel P, Buske J. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1570023223003653\" target=\"_blank\" rel=\"noopener\">All-in-one stability indicating polysorbate 20 degradation root-cause analytics via UPLC-QDa<\/a>, Journal of Chromatography B, Volume 1232, 2024,123955<\/li>\n<li><strong>Herbig ME, Evers DH, Gorissen S, K\u00f6llmer M.<\/strong> <a href=\"https:\/\/www.mdpi.com\/1999-4923\/15\/7\/1822\" target=\"_blank\" rel=\"noopener\">Rational Design of Topical Semi-Solid Dosage Forms-How Far Are We?<\/a> Pharmaceutics 15, 1822, 2023<\/li>\n<li>Sailer MM, <b class=\"\">K\u00f6llmer M<\/b>, Masson B, Fais F, Hohenfeld IP,<b class=\"\"> Herbig ME<\/b>, Koitschev AK &amp; Becker S. <a href=\"http:\/\/doi.org\/10.1080\/03639045.2023.2183724\" target=\"_blank\" rel=\"noopener\">Nasal residence time and rheological properties of a new bentonite-based thixotropic gel emulsion nasal spray \u2013 AM-301<\/a>, Drug Development and Industrial Pharmacy, 2023<\/li>\n<li><strong>Herbig, ME<\/strong>. <a href=\"https:\/\/www.teknoscienze.com\/tks_article\/topical-drug-delivery-and-the-role-of-excipients\/\">Topical Drug Delivery and the Role of Excipients<\/a>, Chimica Oggi &#8211; Chemistry Today, 40 (6), 34-37, 2022<\/li>\n<li>Fronk V, Sch\u00e4ffler M, <strong>Bonyadi H, Herbig ME, K\u00f6llmer M,<\/strong> <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/nadc.20224128025\">Die Produktion pharmazeutischer Emulsionen optimieren<\/a>. Nachrichten aus der Chemie, 70, 49-51, 2022<\/li>\n<li>Kapoor K, Gr\u00e4fe N, <strong>Herbig ME,<\/strong> <a href=\"https:\/\/doi.org\/10.1016\/j.xphs.2022.04.006\">Topical film-forming solid solutions for enhanced dermal delivery of the retinoid tazarotene<\/a>, Journal of Pharmaceutical Sciences, (111), 2779-2787, 2022<\/li>\n<li><strong>Evers DH<\/strong>, Carle S, Lakatos D, H\u00e4mmerling F, Garidel P, Buske J. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1570023221001975\" target=\"_blank\" rel=\"noopener\">Hydrolytic polysorbate 20 degradation \u2013 Sensitive detection of free fatty acids in biopharmaceuticals via UPLC-QDa analytics with isolator column<\/a>, Journal of Chromatography B, Volume 1174, 2021, 122717.<\/li>\n<li><strong>Evers DH<\/strong>, Schultz-Fademrecht T, Garidel P, Buske J. <a href=\"http:\/\/www.doi.org\/10.1016\/j.jchromb.2020.122287\" target=\"_blank\" rel=\"noopener\">Development and validation of a selective marker-based quantification of polysorbate 20 in biopharmaceutical formulations using UPLC QDa detection<\/a>, Journal of Chromatography B, Volume 1157, 2020, 122287.<\/li>\n<li><strong>Puschmann J, Evers DH, <\/strong>M\u00fcller-Goymann CC<strong>, Herbig ME<\/strong>. <a href=\"https:\/\/doi.org\/10.1016\/j.chroma.2019.04.015\" target=\"_blank\" rel=\"noopener noreferrer\">Development of a Design of Experiments optimized method for quantification of polysorbate 80 based on oleic acid using UHPLC-MS<\/a>. J. Chrom. A, (1599): 136-143, 2019.<\/li>\n<li><strong>Puschmann J, Herbig ME,<\/strong> M\u00fcller-Goymann CC. <a href=\"https:\/\/doi.org\/10.1016\/j.ijpharm.2019.02.044\" target=\"_blank\" rel=\"noopener noreferrer\">Influence of emulsifier concentration on partition behavior and chemical stability of betamethasone dipropionate in emulsion gels.<\/a> Int. J. Pharm, (562): 105-112,\u00a02019.<\/li>\n<li><strong>K\u00f6llmer M<\/strong>, <span class=\"authors-affiliations__name\"><span class=\"authors-affiliations__name\">Mossahebi P, Sacharow E, <strong>Gorissen S<\/strong>, Gr\u00e4fe N, <strong>Evers DH<\/strong>, <strong>Herbig ME<\/strong>. <a href=\"https:\/\/doi.org\/10.1208\/s12249-019-1305-3\" target=\"_blank\" rel=\"noopener noreferrer\">Investigation of the Compatibility of the Skin PAMPA Model with Topical Formulation and Acceptor Media Additives Using Different Assay Setups<\/a>. AAPS PharmSciTech, 20(89), 2019.<\/span><\/span><\/li>\n<li><strong>Puschmann J, Herbig ME,<\/strong> M\u00fcller-Goymann CC. <a href=\"https:\/\/doi.org\/10.1016\/j.ejpb.2018.08.007\" target=\"_blank\" rel=\"noopener noreferrer\">Correlation of antimicrobial effects of phenoxyethanol with its free concentration in the water phase of o\/w-emulsion gels.<\/a> Eur J Pharm Biopharm, (131): 152\u2013161, 2018.<\/li>\n<li>Blenner SR, <strong>K\u00f6llmer M,<\/strong> Rouse AJ, Daneshvar N, Williams C, Andrews LB.\u00a0<a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2499265\" target=\"_blank\" rel=\"noopener noreferrer\">Privacy Policies of Android Diabetes Apps and Sharing of Health Information.<\/a> JAMA, 315(10): 1051-52, 2016.<\/li>\n<li><strong>Herbig ME,<\/strong> Houdek P, <strong>Gorissen S,<\/strong> Brandner J et al. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0939641115001630\" target=\"_blank\" rel=\"noopener noreferrer\">A custom tailored model to investigate skin penetration in porcine skin and its comparison with human skin.<\/a> Eur J Pharm Biopharm, (95): 99-109, 2015.<\/li>\n<li><strong>K\u00f6llmer M,<\/strong> Appel A, Somo S, Brey E. <a href=\"https:\/\/doi.org\/10.1089\/ten.teb.2015.0140\" target=\"_blank\" rel=\"noopener noreferrer\">Long-Term Function of Alginate Encapsulated Islets.<\/a> Tissue Engineering Part B: Reviews, 22(1), 2015. DOI: 10.1089\/ten.TEB.2015.0140.<\/li>\n<li>Sharma V, <strong>K\u00f6llmer M,<\/strong> Szymusiak M, Nitsche LC, Gemeinhart RA, Liu Y. <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/bm401550r\" target=\"_blank\" rel=\"noopener noreferrer\">Toroidal-spiral particles for codelivery of anti-VEGFR-2 antibody and irinotecan: a potential implant to hinder recurrence of glioblastoma multiforme.<\/a> Biomacromolecules, 15(3): 756-62, 2014.<\/li>\n<li>Zhang Y, <strong>K\u00f6llmer M,<\/strong> Buhrman JS, Tang MY, Gemeinhart RA. <a href=\"https:\/\/doi.org\/10.1016\/j.peptides.2014.06.008\" target=\"_blank\" rel=\"noopener noreferrer\">Arginine-rich, cell penetrating peptide-anti-microRNA complexes decrease glioblastoma migration potential.<\/a> Peptides, 58: 83-90, 2014.<\/li>\n<li><strong>Herbig ME, Evers DH.<\/strong> <a href=\"https:\/\/doi.org\/10.1016\/j.ejpb.2013.06.022\" target=\"_blank\" rel=\"noopener noreferrer\">Correlation of hydrotropic solubilization by urea with log D of drug molecules and utilization of this effect for topical formulations.<\/a> Eur J Pharm Biopharm, 85(1): 158-160, 2013.<\/li>\n<li><strong>K\u00f6llmer M,<\/strong> Buhrman JS, Zhang Y, Gemeinhart RA. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3765027\/\" target=\"_blank\" rel=\"noopener noreferrer\">Markers Are Shared Between Adipogenic and Osteogenic Differentiated Mesenchymal Stem Cells.<\/a> Journal of Developmental Biology and Tissue Engineering, 5(2): 18-25, 2013.<\/li>\n<li><strong>K\u00f6llmer M,<\/strong> Popescu C, Manda P, Zhou L, Gemeinhart RA. <a href=\"https:\/\/doi.org\/10.1208\/s12249-013-0015-5\" target=\"_blank\" rel=\"noopener noreferrer\">Stability of Benzocaine Formulated in Commercial Oral Disintegrating Tablet Platforms.<\/a> AAPS PharmSciTech, 14(4):1333-40, 2013.<\/li>\n<li><strong>K\u00f6llmer M,<\/strong> Keskar V, Hauk TG, Collins JM, Russell B, Gemeinhart RA. <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/bm300332w\" target=\"_blank\" rel=\"noopener noreferrer\">Stem Cell-Derived Extracellular Matrix Enables Survival and Multilineage Differentiation within Superporous Hydrogels.<\/a> Biomacromolecules, 13(4): 963-973, 2012.<\/li>\n<li>Buhrman JS, Rayahin JE, <strong>K\u00f6llmer M,<\/strong> Gemeinhart RA.<a href=\"https:\/\/doi.org\/10.1186\/1472-6750-12-63\" target=\"_blank\" rel=\"noopener noreferrer\"> In-house preparation of hydrogels for batch affinity purification of glutathione S-transferase tagged recombinant proteins.<\/a>\u00a0BMC Biotechnology, 12(1): 63, 2012.<\/li>\n<li><strong>Herbig ME,<\/strong> Weller K, Merkle HP. <a href=\"http:\/\/www.dl.begellhouse.com\/journals\/3667c4ae6e8fd136,147b6a754b734499,5aba25c43cbb9b51.html\" target=\"_blank\" rel=\"noopener noreferrer\">Reviewing biophysical and cell biological methodologies in cell penetrating peptide research.<\/a> Critical Rev. in Therapeutic Drug Carrier Systems, 24(3): 203-255, 2007.<\/li>\n<li><strong>Herbig ME,<\/strong> Assi F, Textor M, and Merkle HP. <a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/bi050923c\" target=\"_blank\" rel=\"noopener noreferrer\">The cell penetrating peptides pVEC and W2-pVEC induce transformation of gel phase domains in phospholipid bilayers without affecting their integrity.<\/a> Biochemistry, 45(11): 3598-3609, 2006.<\/li>\n<li><strong>Herbig ME,<\/strong> Weller K, Krauss U, Beck-Sickinger AG, Merkle HP, and Zerbe O. <a href=\"https:\/\/doi.org\/10.1529\/biophysj.105.068692\" target=\"_blank\" rel=\"noopener noreferrer\">Membrane surface-associated helices promote lipid interactions and cellular uptake of human calcitonin-derived cell penetrating peptides.<\/a> Biophysical Journal, 89(6): 4056-4066, 2005.<\/li>\n<li><strong>Herbig ME,<\/strong> Fromm U, Leuenberger J, Krauss U, Beck-Sickinger AG, and Merkle HP. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0005273605001045\" target=\"_blank\" rel=\"noopener noreferrer\">Bilayer interaction and localization of cell penetrating peptides with model membranes.<\/a> Biochimica et Biophysica Acta-Biomembranes, 1712(2): 197-211, 2005.<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; 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