{"id":74720,"date":"2022-06-02T09:59:41","date_gmt":"2022-06-02T07:59:41","guid":{"rendered":"https:\/\/rades-development.com\/?page_id=74720"},"modified":"2022-06-03T15:37:05","modified_gmt":"2022-06-03T13:37:05","slug":"performance-testing","status":"publish","type":"page","link":"https:\/\/rades-development.com\/en\/services\/performance-testing\/","title":{"rendered":"Performance Testing"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243;][vc_column column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; zoom_width=&#8221;0&#8243; zoom_height=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_column_text el_class=&#8221;rades-main-headline&#8221; uncode_shortcode_id=&#8221;518325&#8243;]<\/p>\n<div class=\"rades-main-headline-icon\"><img decoding=\"async\" src=\"https:\/\/rades-development.com\/wordpress\/wp-content\/uploads\/2018\/01\/rades-icon-1.png\" \/><\/div>\n<div class=\"rades-main-headline-content\"><span class=\"rades-main-headline-text\">4. Performance testing &#8211; In vitro &amp; EX VIVO models for percutaneous absorption<br \/>\n<\/span><\/div>\n<p>[\/vc_column_text][vc_column_text uncode_shortcode_id=&#8221;196247&#8243;]<\/p>\n<div>\n<p><span lang=\"EN-GB\">RaDes established a range of powerful in vitro and ex vivo models for de-risking dermal development projects and to assess the quality and performance of topical products. These models provide support through the entire lifecycle of a drug product from compound and formulation selection to bioequivalence testing and post-approval changes. High-performance analytical equipment is in place for selective and sensitive analysis.<\/span><\/p>\n<\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;1&#8243; back_color=&#8221;color-375106&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;134300&#8243; back_color_type=&#8221;uncode-palette&#8221;][vc_column column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; zoom_width=&#8221;0&#8243; zoom_height=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row-first&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_column_text el_class=&#8221;rades-main-headline&#8221; uncode_shortcode_id=&#8221;730823&#8243;]<\/p>\n<div class=\"rades-smaller-headline-icon\"><img decoding=\"async\" src=\"https:\/\/rades-development.com\/wordpress\/wp-content\/uploads\/2018\/01\/rades-icon-column-3.png\" \/><\/div>\n<div class=\"rades-smaller-headline-content\"><span class=\"rades-smaller-headline-text\">In vitro release test (IVRT) using vertical diffusion cells<\/span><\/div>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243;][vc_column_text uncode_shortcode_id=&#8221;476666&#8243; css=&#8221;.vc_custom_1654174285396{padding-left: 60px !important;}&#8221;]<\/p>\n<ul style=\"font-weight: 400;\">\n<li>Determination of in vitro drug release rate through an artificial membrane<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Ranking and selection of formulation prototypes for dermal or transdermal application<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Evaluation of equivalence of topical products for generic submissions as required according to the \u201cEMA Draft guideline on quality and equivalence of topical products\u201d<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Scale-up and post approval changes (according to FDA\u2019s SUPACC SS)<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Support from initial assessment up to fully validated methods according to OECD, FDA, or EMA, including analytical method validation according ICH guidelines.<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Robotic diffusion system with dry-heat blocks and optimized stirring to obtain superior data quality. 12 parallel vertical diffusion cells in place<\/li>\n<li>For introduction and examples on IVRT see RaDes webinar recording <a href=\"https:\/\/www.youtube.com\/watch?v=N5dipRLQuYU\" target=\"_blank\" rel=\"noopener\">here (YouTube)<\/a>.<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_empty_space empty_h=&#8221;0&#8243;][vc_single_image media=&#8221;74566&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;45&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;202869&#8243;][vc_single_image media=&#8221;74466&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;45&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;114365&#8243;][vc_single_image media=&#8221;74583&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;45&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;996324&#8243;][vc_empty_space empty_h=&#8221;2&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;2&#8243; bottom_padding=&#8221;2&#8243; back_color=&#8221;color-375106&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;142441&#8243; back_color_type=&#8221;uncode-palette&#8221;][vc_column column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; zoom_width=&#8221;0&#8243; zoom_height=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row-first&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_column_text el_class=&#8221;rades-main-headline&#8221; uncode_shortcode_id=&#8221;209834&#8243;]<\/p>\n<div class=\"rades-smaller-headline-icon\"><img decoding=\"async\" src=\"https:\/\/rades-development.com\/wordpress\/wp-content\/uploads\/2018\/01\/rades-icon-column-3.png\" \/><\/div>\n<div class=\"rades-smaller-headline-content\"><span class=\"rades-smaller-headline-text\">In vitro permeation test (IVPT) using vertical diffusion cells<\/span><\/div>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243;][vc_column_text uncode_shortcode_id=&#8221;124608&#8243; css=&#8221;.vc_custom_1654174545665{padding-left: 60px !important;}&#8221;]<\/p>\n<ul style=\"font-weight: 400;\">\n<li>Evaluation of the characteristic permeation profile of the drug\/ingredient(flux rate &amp; permeated amount) through animal or human skin<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Lead compound and formulation prototype selection to de-risk clinical program<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Bioequivalence (BE) studies for topical generic development according to EMA \u201cDraft guideline on quality and equivalence of topical products\u201d<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Absorption studies for safety of chemicals, pesticides etc. according OECD 428<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>In vitro dermal absorption studies of cosmetic \/ consumer products according to Scientific Committee on Consumer Safety (SCCS) guidance document<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Scale-up and post-approval changes (SUPAC SS)<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Support from initial assessment up to fully validated methods according to OECD, FDA, or EMA, including analytical method validation according to ICH guidelines.<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Investigation of distribution between epidermis and dermis (heat splitting)<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Inhouse preparation of pig ear skin samples established to use fresh pig skin in IVPT studies on demand<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Optionally, use of Strat-M<sup>\u00ae<\/sup> artificial, non-animal-based membrane as screening tool for skin permeation of topical formulations and for transdermal patches<\/li>\n<li>Robotic diffusion system with dry-heat blocks and optimized stirring to obtain superior data quality. 12 parallel vertical diffusion cells in place<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_empty_space empty_h=&#8221;0&#8243;][vc_single_image media=&#8221;74587&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;50&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;164717&#8243;][vc_single_image media=&#8221;74589&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;50&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;344440&#8243;][vc_single_image media=&#8221;74598&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;50&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;922528&#8243;][vc_single_image media=&#8221;74593&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;50&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;207488&#8243;][vc_empty_space empty_h=&#8221;2&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;1&#8243; bottom_padding=&#8221;2&#8243; back_color=&#8221;color-375106&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;208559&#8243; back_color_type=&#8221;uncode-palette&#8221;][vc_column column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; zoom_width=&#8221;0&#8243; zoom_height=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row-first&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_column_text el_class=&#8221;rades-main-headline&#8221; uncode_shortcode_id=&#8221;719755&#8243;]<\/p>\n<div class=\"rades-smaller-headline-icon\"><img decoding=\"async\" src=\"https:\/\/rades-development.com\/wordpress\/wp-content\/uploads\/2018\/01\/rades-icon-column-3.png\" \/><\/div>\n<div class=\"rades-smaller-headline-content\"><span class=\"rades-smaller-headline-text\">Ex vivo skin penetration model (Hamburg model)<\/span><\/div>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243;][vc_column_text uncode_shortcode_id=&#8221;133584&#8243; css=&#8221;.vc_custom_1654175294193{padding-left: 60px !important;}&#8221;]<\/p>\n<ul style=\"font-weight: 400;\">\n<li>Skin penetration model using viable pig ear skin. Excellent correlation with human skin demonstrated<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Allows determination of cutaneous biodistribution of topically applied drugs<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Penetration profile into different skin layers. Direct determination of actives concentration at the site of action possible.<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Cost effective and without ethical implications<\/li>\n<li>In cooperation with university hospital Hamburg Eppendorf (UKE). Analytical method development, sample preparation and analysis at RaDes<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Viable model which allows determination of metabolism of actives in the skin<\/li>\n<li>See: <a href=\"https:\/\/doi.org\/10.1016\/j.ejpb.2015.03.030\" target=\"_blank\" rel=\"noopener\">Herbig ME, Houdek P, Gorissen S, Brandner J et al. A custom-tailored model to investigate skin penetration in porcine skin and its correlation with human skin. Eur J Pharm Biopharm, (95) 99-109, 2015<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_empty_space empty_h=&#8221;0&#8243;][vc_single_image media=&#8221;74669&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;45&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;927173&#8243;][vc_single_image media=&#8221;74671&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;45&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;455235&#8243;][vc_single_image media=&#8221;74673&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;45&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;195939&#8243;][vc_single_image media=&#8221;74675&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;45&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;917908&#8243;][vc_empty_space empty_h=&#8221;3&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;1&#8243; bottom_padding=&#8221;2&#8243; back_color=&#8221;color-375106&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;367722&#8243; back_color_type=&#8221;uncode-palette&#8221;][vc_column column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; zoom_width=&#8221;0&#8243; zoom_height=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row-first&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_column_text el_class=&#8221;rades-main-headline&#8221; uncode_shortcode_id=&#8221;496132&#8243;]<\/p>\n<div class=\"rades-smaller-headline-icon\"><img decoding=\"async\" src=\"https:\/\/rades-development.com\/wordpress\/wp-content\/uploads\/2018\/01\/rades-icon-column-3.png\" \/><\/div>\n<div class=\"rades-smaller-headline-content\"><span class=\"rades-smaller-headline-text\">Skin Pampa<\/span><\/div>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243;][vc_column_text uncode_shortcode_id=&#8221;160964&#8243; css=&#8221;.vc_custom_1654175684040{padding-left: 60px !important;}&#8221;]<\/p>\n<ul style=\"font-weight: 400;\">\n<li>Screening tool for dermal permeation potential<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>96-well plate format using a porous lipid-impregnated filter to mimic the stratum corneum as the main barrier for dermal absorption<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>Allows comparison of topical and transdermal formulations to support ranking &amp; selection<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>RaDes investigations contributed to the understanding of the potential and limits of the model. See: <a href=\"https:\/\/doi.org\/10.1208\/s12249-019-1305-3\" target=\"_blank\" rel=\"noopener\">K\u00f6llmer M et al. Investigation of the Compatibility of the Skin PAMPA Model with Topical Formulation and Acceptor Media Additives Using Different Assay Setups. AAPS PharmSciTech, 20(89), 2019.<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_empty_space empty_h=&#8221;0&#8243;][vc_single_image media=&#8221;74682&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;45&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;561424&#8243;][vc_single_image media=&#8221;74684&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;45&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;964767&#8243;][vc_empty_space empty_h=&#8221;2&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;1&#8243; bottom_padding=&#8221;2&#8243; back_color=&#8221;color-375106&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;188266&#8243; back_color_type=&#8221;uncode-palette&#8221;][vc_column column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; zoom_width=&#8221;0&#8243; zoom_height=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row-first&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_column_text el_class=&#8221;rades-main-headline&#8221; uncode_shortcode_id=&#8221;210438&#8243;]<\/p>\n<div class=\"rades-smaller-headline-icon\"><img decoding=\"async\" src=\"https:\/\/rades-development.com\/wordpress\/wp-content\/uploads\/2018\/01\/rades-icon-column-3.png\" \/><\/div>\n<div class=\"rades-smaller-headline-content\"><span class=\"rades-smaller-headline-text\">Nail penetration model<\/span><\/div>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243;][vc_column_text uncode_shortcode_id=&#8221;135287&#8243; css=&#8221;.vc_custom_1654175947379{padding-left: 60px !important;}&#8221;]<\/p>\n<p style=\"font-weight: 400;\">The nail is a barrier fundamentally different to the skin and requires different formulation approaches and penetration models<\/p>\n<p>&nbsp;<\/p>\n<ul style=\"font-weight: 400;\">\n<li>Inhouse developed model using human nail clippings to determine the API amount penetrated into the nail plate<\/li>\n<li>As nail swelling facilitates penetration, formulations can also be characterized with regards to their nail swelling capacity<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_empty_space empty_h=&#8221;0&#8243;][vc_single_image media=&#8221;74689&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;40&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;106355&#8243;][vc_single_image media=&#8221;74691&#8243; media_lightbox=&#8221;yes&#8221; media_width_percent=&#8221;40&#8243; alignment=&#8221;center&#8221; lbox_skin=&#8221;white&#8221; custom_cursor=&#8221;accent&#8221; uncode_shortcode_id=&#8221;147020&#8243;][vc_empty_space empty_h=&#8221;3&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;1&#8243; bottom_padding=&#8221;3&#8243; back_color=&#8221;color-375106&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;142278&#8243; back_color_type=&#8221;uncode-palette&#8221;][vc_column column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; zoom_width=&#8221;0&#8243; zoom_height=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row-first&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243;][vc_column_text el_class=&#8221;rades-main-headline&#8221; uncode_shortcode_id=&#8221;208695&#8243;]<\/p>\n<div class=\"rades-smaller-headline-icon\"><img decoding=\"async\" src=\"https:\/\/rades-development.com\/wordpress\/wp-content\/uploads\/2018\/01\/rades-icon-column-3.png\" \/><\/div>\n<div class=\"rades-smaller-headline-content\"><span class=\"rades-smaller-headline-text\">Your contact on this topic<\/span><\/div>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;rades-why-rades-row&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;2&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243;][vc_column_text uncode_shortcode_id=&#8221;742154&#8243; css=&#8221;.vc_custom_1654263420695{padding-left: 60px !important;}&#8221;]<\/p>\n<p style=\"font-weight: 400;\">Sascha Gorissen<br \/>\n<a href=\"tel:+4915112986843\">+49 151 12986843<\/a><br \/>\n<a href=\"mailto:sascha.gorissen@rades-development.com\">sascha.gorissen@rades-development.com<\/a><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_empty_space empty_h=&#8221;0&#8243;][vc_single_image media=&#8221;73295&#8243; 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