{"id":74829,"date":"2022-10-07T16:39:50","date_gmt":"2022-10-07T14:39:50","guid":{"rendered":"https:\/\/rades-development.com\/?page_id=74829"},"modified":"2022-10-07T16:39:50","modified_gmt":"2022-10-07T14:39:50","slug":"news-2-2","status":"publish","type":"page","link":"https:\/\/rades-development.com\/en\/news-2-2\/","title":{"rendered":"News (Test 2)"},"content":{"rendered":"

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News – We inform you regularly<\/span><\/div>\n

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RaDes poster on rheological equivalence testing of topical generics<\/span><\/p>\n<\/div>\n

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Topical dermatological generics must be characterized also for rheological equivalence to the originator. The EMA \u201cDraft guideline on quality and equivalence of topical products\u201d from 2019 provides specific guidance on how this should be performed.<\/p>\n

The parameters to be investigated include viscosity values at different shear rates (viscosity curve), thixotropy testing, yield stress, as well as viscoelastic storage and loss moduli. This requires a high-performance rheometer and expertise to conduct, evaluate, and interpret the specific experiments.<\/p>\n

RaDes presented a poster on \u201cEquivalence testing of rheological parameters of generic and branded cream, facing criteria of EMA Draft Guideline 2019\u201d at the \u201cInnovations in Dermatological Sciences Conference\u201d at the Center for Dermal Research, New Jersey, on September 28th<\/sup> and 29th<\/sup>. As we demonstrated, the proposed criteria appear very strict, especially as the variability in some parameters is high even between commercial batches of approved products. The EMA guidance is still in draft but likely to be considered \u201dstate of the art\u201d by the EMA. Some deviations from the proposed guideline may be possible, but should be agreed with authorities in advance based on a robust scientific rationale. Therefore, next to the rheological capabilities, a sound understanding of formulation design and of appropriate statistical evaluation are important.<\/p>\n

The poster can be downloaded here<\/a>.<\/strong> If you have questions on the rheological equivalence testing or if you want to learn more on how rheological characterization helps to design and optimize formulations and processes, please get in touch: michael.herbig@rades-development.com<\/a><\/p>\n

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4-year anniversary of RaDes<\/span><\/p>\n<\/div>\n

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On a beautiful summer day in Hamburg we celebrated our 4th anniversary at\u00a0RaDes GmbH with some nice drinks and food!<\/p>\n

Many thanks to all our clients, partners and friends for the great collaboration during this time![\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

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Internship project on Design of Experiment-optimized creams<\/span><\/p>\n<\/div>\n

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Felix Teschke, pharmacist in the year of practical training from the university of Greifswald is completing his 6 months internship at RaDes. He dealt with the basics of the transformation of topical formulations after application. Furthermore, he has performed a Design of Experiment (DoE)-based optimization of consistency agent-containing cream formulations, especially, with respect to the ideal ratio between hydrophilic emulsifier and co-emulsifier. The results obtained are very valuable for a rational development of such creams.<\/p>\n

Felix’s hobby is 3D printing. We have taken advantage of this to equip our labs with some self-printed, helpful tools to facilitate work processes. For example, a holder that enables particularly thorough cleaning of glass slides for sensitive microscopic examinations, or a device for microscopy slides that allows fast, safe handling of these in evaporation profile studies of topical formulations!<\/p>\n

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How rheology can be used to develop better semi-solid products & processes<\/span><\/p>\n<\/div>\n

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Melanie K\u00f6llmer from RaDes presented case studies on how rheology and particle size characterization helped to develop and optimize semisolid formulations in the Anton Paar webinar \u201cA recipe for success: Combining rheology and particle characterization for pharmaceutical and cosmetic product formulation\u201d.<\/p>\n

Rheology and particle characterization are great tools to improve the design, process development and control of semi-solid formulations. Especially rheology offers great potential from supporting the design of attractive sensory properties to optimizing stability and diagnosing issues. In addition, increasingly comprehensive rheological characterization is requested by authorities, especially in the context of generic development projects.<\/p>\n

Rheology is most powerful, if combined with the knowledge on formulation design and the inner structures of semisolid formulations as well as on regulatory requirements, industrial processes and constraints of quality control. Different questions require different experimental setups and evaluation of different rheological parameters.<\/p>\n

In case you missed the presentation, you can download it here<\/strong><\/a>.<\/p>\n

If you\u2019re interested to learn more about how rheological characterization may help for the success for your project, please contact Melanie at: melanie.koellmer@rades-development.com<\/a> and let\u2019s discuss![\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

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RaDes wishes happy holidays!<\/span><\/p>\n<\/div>\n

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Welcome Elina!<\/span><\/p>\n<\/div>\n

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In November 2021, Dr. Elina Hagelskamp joined RaDes as analytical scientist. Elina obtained her Master\u2019s degree in chemistry from LMU Munich with distinction. In her PhD project in organic analytical chemistry she focused on the investigation of catalytically active molecules in the context of prebiotic chemistry and identified a class organocatalysts with potential relevance to the origin of life. In this project, she gained expertise in various applications of chromatography and mass spectrometry. Together with her sound knowledge of organic chemistry and a special interest for mathematics, she will be an important part of the analytics team at RaDes. Her focus at RaDes is analytical method development, stability investigations and in vitro release & permeation testing.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

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Bentrio\u2122 – a nasal spray for protection against airborne viruses, developed with contributions from RaDes<\/span><\/p>\n<\/div>\n

[\/vc_column_text][vc_column_text]\"\"BentrioTM<\/sup> is a nasal spray which is designed to help people to protect themselves against airborne viruses and allergens. It was developed by Altamira Medica, a Swiss company, \u00a0and\u00a0 recently got launched in Germany with more countries to follow. At RaDes, we are proud that we were able to contribute to the development of its formulation through our collaboration with Altamira.<\/p>\n

BentrioTM<\/sup> acts by forming a thin protective layer on the nasal mucosa. Based on physical principles, it can trap viruses such as SARS-CoV-2 and thus reduce the viral load in the nose.<\/p>\n

Considering the challenges from the current and potential future virus variants, Bentrio can provide additional protection against Covid-19 in combination with vaccinations and general hygiene measures.<\/p>\n

To make this possible, several interesting formulation challenges needed to be resolved: the choice of the right type and \u00a0concentration of two key components, a mineral-based thickener and triglyceride, and the perfect rheological profile. The formulation liquifies under shaking to become nicely sprayable; following application to the nose, it quickly recovers viscosity to form a thin protective film on the nasal mucosa without running off (a quick \u201cthixotropic recovery\u201d in the words of rheology).<\/p>\n

For more information see: www.bentrio.com<\/a><\/p>\n

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Internship project on particle size measurements of emulsions<\/span><\/div>\n

[\/vc_column_text][vc_column_text]\"\"Particle size determination of emulsions and suspensions plays an important role in formulation and process development and control. Measurement by laser diffraction offers many advantages such as the measurement of thousands of particles within seconds, a wide measurement range as well as high accuracy and reproducibility.<\/p>\n

However, often emulsions are more complex than just \u201coil droplets in water\u201d. For example, gel phase structures formed from emulsifiers and co-emulsifiers may exist in parallel to the oil droplets. This raises the question if there are methods which are suitable of determining both species in parallel or procedures that could reliably \u201cdestroy\u201d the gel phases to determine the primary oil droplet size only. Also, in some emulsions, oil droplets may be covered by multiple layers of emulsifiers which may or may not be subject to change during sample preparation.<\/p>\n

In addition, the choice of the appropriate model for data processing is not always trivial: The Fraunhofer model requires only few input parameters but will lose validity for small particle sizes whereas the more universal Mie model requires more input parameters.<\/p>\n

Hossa Bonyadi, pharmacist in the year of practical training from the university of Marburg, addresses such questions during her 6 months internship at RaDes. She performs the studies on a PSA 1090 particle sizer from Anton Paar GmbH. Her results will help to choose the appropriate sample preparation and evaluation models for different formulation types and help in the interpretation of particle size distribution data of complex emulsions.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

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3 Years of RaDes!<\/span><\/div>\n

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Three years ago, at the beginning of July 2018, we started RaDes. From scratch. That means: building the labs, acquiring instruments, creating a website, considering when it was the right time to approach the first potential clients, etc. Hard work and quite a bit of uncertainty during a hot summer.<\/p>\n

This seems so long ago now. In the meantime, we\u2019ve established great partnerships with many clients and successfully solved a variety of development challenges from formulating actives to developing analytical methods to improving the robustness of existing products.<\/p>\n

We\u2019re now serving customers in Germany, Switzerland, France, UK, Austria, Slovakia and the USA. Some first products which we\u2019ve developed already reached the market. We\u2019re establishing a QMS, published papers, filed a patent, gave lectures and talks and continued to learn so much from collaborations and discussions. We hired new colleagues and continuously expanded our instrumentation.<\/p>\n

Thank you to all our clients, partners, friends and, in particular, to our great team who made this possible!<\/p>\n

A lot to celebrate \u2013 due to the pandemic, still with restricted opportunities to do so.<\/p>\n

For now, we started with a delicious cake. Soon, the whole RaDes team will be fully vaccinated and we\u2019ll take the opportunity to catch up with celebrating together![\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

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RaDes portrayed in Waters case study<\/span><\/div>\n

[\/vc_column_text][vc_column_text]For chromatography and mass spectrometry, we have acquired several instruments from Waters – a world leading manufacturer in this field.
\nWaters found our history and projects interesting and published a case study on us based on an extensive interview with our head of laboratory Sascha Gorissen.
\nRead the report with interesting insights at: Case Study RaDes – Waters<\/a>\"\"<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

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New publication on sensitive detection method of free fatty acids in biopharmaceuticals<\/span><\/div>\n

[\/vc_column_text][vc_column_text]Following up on the last year\u2019s publication on a novel quantification method for polysorbate 20, now a paper focusing on the detection of free fatty acids in biopharmaceuticals via UPLC-QDa analytics was published. Again, Dirk Evers from RaDes made essential contributions to this work.<\/p>\n

Sensitive and robust quantification of fatty acids (FA) is essential for the monitoring, understanding and potential improvement of the stability of polysorbates in biopharmaceutical formulations.<\/p>\n

FA may be released over time by enzymatic degradation of polysorbates caused by traces of host cell enzymes in biologics. Due to their low aqueous solubility, fatty acids may precipitate as particles which is an important concern for quality and safety.<\/p>\n

The method presented offers several advantages for convenient monitoring of FA release: It is label-free and allows the determination of released FAs as percentage of ester bond hydrolysis and as absolute concentration. Additionally, by using an isolator column to remove trace levels of FAs present in the eluents the sensitivity of the method is improved. It was the first time in FA analysis that such a procedure was successfully employed.<\/p>\n

For more information, see the full publication at https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1570023221001975<\/a> or contact us at info@rades-development.com<\/a><\/p>\n

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UPLC & QDa number 3 at RaDes!<\/span><\/div>\n

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For what we do at RaDes, the Waters UPLC system equipped with e\u03bb-PDA (UV\/VIS) plus QDa (single mass) detectors proofed to be extremely useful. Therefore, to support our growth, we just got our third one installed!
\nThe system permits us to speed up method development and the rapid analysis also of larger quantities of stability and IVRT samples. Thanks to the QDa mass spec detector, it allows the detection of also poorly UV-active compounds with high sensitivity and the identification of co-eluting compounds.<\/p>\n

An instructive example of how this adds value to challenging analytical projects, you may have a look at the recent publication on identification and quantification of the complex mixture of subspecies in polysorbate 20: https:\/\/doi.org\/10.1016\/j.jchromb.2020.122287<\/a>.<\/p>\n

Many thanks to Waters for the continued great cooperation![\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ desktop_visibility=”yes” medium_visibility=”yes” mobile_visibility=”yes” inverted_device_order=”yes” el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

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RaDes unterst\u00fctzt “Jugend forscht”<\/span><\/div>\n

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Der \u201eJugend forscht\u201c-Wettbewerb ist eine gro\u00dfartige M\u00f6glichkeit f\u00fcr Jugendliche, ihr Talent in einem selbstgew\u00e4hlten wissenschaftlichen Projekt auszuprobieren und weiterzuentwickeln. Zum dritten Mal in den zweieinhalb Jahren seit Bestehen unterst\u00fctzte RaDes den \u201eJugend forscht\u201c Regionalwettbewerb Hamburg Volkspark durch zwei Juroren im Bereich \u201eChemie\u201c (https:\/\/www.hamburg.jugend-forscht.de<\/a>).<\/p>\n

In diesem Jahr haben Melanie K\u00f6llmer und Dirk Evers eine Reihe spannender Projekte von jungen naturwissenschaftlichen Talenten begutachtet \u2013 Pandemie-bedingt in einem reinen Online-Format. Zum zweiten Mal hat die RaDes GmbH dabei ein Schnupperpraktikum in den RaDes Laboratorien als Sonderpreis f\u00fcr ein herausragendes Projekt vergeben. Wir freuen uns, auf diesem Weg einen Beitrag zur F\u00f6rderung und Begeisterung junger Menschen f\u00fcr die Forschung & Entwicklung zu leisten.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

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RaDes wishes Merry Christmas!<\/span><\/div>\n

[\/vc_column_text][vc_column_text]\"\"[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

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New publication: novel quantification method for polysorbate 20 <\/span><\/div>\n

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Polysorbates are used in around 70% of all biopharmaceutical formulations as generally safe and effective stabilizers. However, in recent years, the risk of particle formation in parenterals caused by chemical or enzymatic degradation of polysorbates gained attention.<\/p>\n

Polysorbates are complex mixtures; theoretically, the number of possible subspecies may be infinite. To enable the mitigation of risks, powerful and reliable analytical methods are necessary which allow separation, identification, and quantification of the subspecies. This then enables a mechanistic understanding of degradation pathways as basis for improved product safety.<\/p>\n

We are pleased that now, with essential contributions of Dirk Evers from RaDes, a novel method for the selective marker-based quantification of polysorbate 20 in biopharmaceutical formulations was published. Using a modern Waters UPLC-H Class with selective QDa detector, 676 subspecies could be assigned. For a representative selection of 41 markers a quantification method was developed and validated.<\/p>\n

For the full article see: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1570023220300143?via%3Dihub<\/a><\/p>\n

Contact: info@rades-development.com<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

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Welcome aboard, Mandy!<\/span><\/div>\n

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As of mid-August 2020, Mandy Rosenberger, joined our team as chemical laboratory technician. She has several years of practical work experience in the laboratory and is familiar with a wide range of analytical methods. Her main focus at RaDes is sample preparation of semi-solid formulations, chromatography with UV\/Vis and mass spectrometric detection, as well as support in the manufacturing of formulations.<\/p>\n

We are very happy that Mandy is now part of our team![\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

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RaDes is also there for its customers during the Corona pandemic<\/span><\/div>\n

[\/vc_column_text][vc_column_text]For two months now, life and work have been strongly influenced by the effects of the Corona pandemic.<\/p>\n

At RaDes, we took early action and prepared ourselves. Anticipating and mitigating risks is a well-established practice for us. We are stocked with important materials (eluents, excipients) and hold our meetings virtually to avoid non-essential contacts.<\/p>\n

An important finding is that it has paid off that we have invested in a powerful IT infrastructure from the very beginning: every employee has a notebook, data and analysis instruments can be securely accessed from home. Our laboratory operations continue in accordance with official regulations and a “backup team” working from home is in place to ensure business continuity and to be reliably available for our customers.
\nWe take the situation seriously in order to protect the health of our employees and to act far-sighted and socially responsibly. We also do not lose sight of what was important before “Corona” and is crucial for the future: many things that make up good development work will continue to exist. Some things will change. The use of modern technology and digitalisation is changing from “nice to have” to a must have in many areas.<\/p>\n

Finally, we would like to take this opportunity to thank our customers, suppliers and business partners. During this time, we have had many positive experiences of friendly and constructive cooperation and commitment to move things forward together in spite of obstacles.
\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
Internship Project on Rheology<\/span><\/div>\n

[\/vc_column_text][vc_column_text]\"\"<\/p>\n

As of May, Manasse Feichtinger started a six-month internship at RaDes as part of his compulsory training as pharmacist. Manasse studied pharmaceutical sciences at the university of Marburg; in addition to that, he is a trained laboratory technician with experience in the analysis of semi-solid formulations.<\/p>\n

At RaDes, Manasse is going to investigate rheological characteristics of semi-solid excipients and formulations, including oscillatory studies that allow deeper insights to the inner structure of materials, as well as thermo-rheology.<\/p>\n

A particular focus is to what extent materials from different suppliers, which all comply with pharmacopeial specifications, show rheological differences that may be relevant for stability, process development, and performance. In addition, it will be investigated how rheological features of pure structure-giving excipients relate to their performance after incorporation in a formulation.<\/p>\n

In RaDes\u2019 second year of existence, this is our first student project. As we are committed to the development of talents, innovation, and the ambition to understand semi-solid formulations more and more systematically, we expect that more will follow![\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
RaDes has implemented Germany\u2019s first Phoenix\u2122 Robotic Diffusion Station with dry heat diffusion cells<\/span><\/div>\n

[\/vc_column_text][vc_column_text]\"\"<\/p>\n

Lack of control over variability factors can compromise data quality of in vitro release testing and cause ambiguity in the assessment of skin permeation.<\/p>\n

We are proud of having implemented Germany\u2019s first Phoenix\u2122 RDS (Robotic Diffusion Station) with dry heat diffusion cells and being able to offer the benefits of this technology to our customers.<\/p>\n

Its advantages versus the traditional technology of in vitro permeation testing include a significantly better temperature control provided by the Phoenix dry heat system as compared to circulating water baths systems. As diffusion is a function of temperature, this improves data quality. Similarly, a superior control of mixing speed is achieved. In addition, reduced maintenance and faster setup making it more economical.<\/p>\n

Many thanks to Bruna Lousada from Teledyne Hansen Research and Severin Schweisthal & Antony Wozniak from Cole Parmer for the great collaboration and support!<\/p>\n

www.hansonresearch.com\/diffusion-testing\/phoenix-dry-heat-systems<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
Petra Lohmann joins RaDes as Head of QA<\/span><\/div>\n

[\/vc_column_text][vc_column_text]\"\"<\/a>We are very pleased that Dr. Petra Lohmann joined the RaDes team at the beginning of January 2020 as head of quality assurance.
\nPetra Lohmann has more than 20 years of experience in quality control and quality assurance in responsible positions, which makes her extensively familiar with quality requirements for pharmaceuticals, medical devices, cosmetics and biocides.
\nShe is responsible for the development and maintenance of the quality management system at RaDes and offers consulting services and expert statements in the field of quality management.
\nFurther information is available at: https:\/\/rades-development.com\/en\/about-rades\/team\/dr-petra-lohmann\/<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ desktop_visibility=”yes” medium_visibility=”yes” mobile_visibility=”yes” inverted_device_order=”yes” el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
RaDes in 5 min, 42 sec<\/span><\/div>\n

[\/vc_column_text][vc_column_text]RaDes war eingeladen, sich auf der \u201eIns Netz gegangen\u201c-Veranstaltung von Life Science Nord zu pr\u00e4sentieren. Die einzige Regel des Events, das am 27.11.19 in L\u00fcbeck stattfand, war: die Pr\u00e4sentation darf maximal 6 Minuten dauern. Michael Herbig, Gesch\u00e4ftsf\u00fchrer von RaDes, hat die Firma in 5 Minuten und 42 Sekunden vorgestellt und sich \u00fcber die interessanten Diskussionen mit anderen Netzwerkmitgliedern im Anschluss gefreut!
\nUnter “RaDes bei Life Science Nord”<\/a> finden Sie unsere Pr\u00e4sentation, f\u00fcr die Sie sich so viel Zeit nehmen k\u00f6nnen, wie Sie m\u00f6chten.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
Our Chemical Laboratory Technician Awarded for Outstanding Performance!<\/span><\/div>\n

[\/vc_column_text][vc_column_text]On 20.09.2019 our employee Janek Giebel was awarded by the Chamber of Industry and Commerce of L\u00fcbeck for his outstanding performance in the final examination as a chemical laboratory technician. We congratulate him very much and are happy that he enriches our team with his excellent work! [\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
RaDes presented poster on rheological characterization at Skin Forum in Reims<\/span><\/div>\n

[\/vc_column_text][vc_column_text]\"\"<\/a>On 23 \u2013 24 September Melanie K\u00f6llmer and Michael Herbig attended the Skin Forum in Reims, France. They enjoyed the scientific program with many interesting and relevant contributions and the inspiring discussions with other participants. Also, our poster \u201cDifferences in shear viscosities in the non-plateau region of the viscosity curve and implications for rheological method development and release testing of semisolid products\u201d was well received and led to interesting discussions. For more information on services we offer around rheological characterization of formulation have look at our attached flyer.<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
Welcome aboard, Janek! <\/span><\/div>\n

[\/vc_column_text][vc_column_text]\"\"<\/p>\n

As of July, Janek Giebel has joined the RaDes team! He very successfully finished his apprenticeship to become a chemical laboratory technician in June 2019. During his training he already collected 3 years of experience in the analysis of semi-solid formulations.<\/p>\n

Janek will mainly support us in analytical work (HPLC, UPLC, MS) as well as in galenic development and testing of liquid and semi-solid products.<\/p>\n

We are happy that Janek is part of our team![\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
Expansion of our analytical equipment<\/span><\/div>\n

[\/vc_column_text][vc_column_text]\"\"<\/p>\n

After a successful first year we have extended our modern analytical equipment with an additional Waters ACQUITY\u2122 UPLC\u2122- H-Class with PDA & QDa (single mass spectrometer) detectors. The new system is also equipped with a solvent selection valve (6 mobile phases) and a column manager (up to 4 columns) and is therefore ideally suited for method development as well as for the analysis of large sample quantities.<\/p>\n

All our HPLC and UPLC\u2122 instruments are operated with the latest version of the chromatography data system Empower\u2122 3 (Service Release 3) from Waters GmbH to ensure high quality data management.<\/p>\n

The new equipment allows us to further increase our capacity and flexibility in handling customer projects.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
1 Year of RaDes!<\/span><\/div>\n

[\/vc_column_text][vc_column_text]At the beginning of July 2018, the history of RaDes began with the set-up of the laboratories and the creation of the website. In September the founding team was complete, in November the laboratories were fully operational. And after one year we are an established, growing development service provider!<\/p>\n

We are grateful for the many positive experiences and collaborations and would like to thank our customers, partners, friends and look forward to further collaborations!<\/p>\n

\"\"[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
Three new publications by RaDes scientists<\/span><\/div>\n

[\/vc_column_text][vc_column_text]In the first months of this year, three research papers were published by RaDes scientists. These address different aspects with high practical relevance for the systematic development of liquid and semi-solid formulations:<\/p>\n

The first paper published was a systematic evaluation of the Skin PAMPA model (\u2018Investigation of the Compatibility of the Skin PAMPA Model with Topical Formulation and Acceptor Media Additives Using Different Assay Setups\u2019). In this, the general compatibility of the model with non-aqueous formulation systems was demonstrated and solvent concentrations above which there is a risk of extraction of lipids from the membrane were established. In addition, the potentials and limitations of a modified setup placing the donor on top were described.
\nDOI: https:\/\/doi.org\/10.1208\/s12249-019-1305-3<\/a><\/p>\n

Furthermore, the influence of the aqueous concentration of betamethasone dipropionate on its stability in emulsion gels was investigated. It could be shown that with increasing emulsifier concentration more active substance was distributed into the water phase which causes increased degradation. The methods and insights pave the way to formulation options to stabilize hydrolysis-prone actives by “entrapping” them in the oil phase. DOI
\nDOI: https:\/\/doi.org\/10.1016\/j.ijpharm.2019.02.044<\/a><\/p>\n

In order to determine the emulsifier content in the water phase, a new method for quantifying polysorbate 80 was developed. This means that polysorbate 80 can also be determined in concentrations far below the critical micelle formation concentration. Using a DoE approach, it was also possible to determine how the oleic acid contained in this highly complex mixture can be reliably determined in the presence of isomeric C18:1 acids.
\nDOI: \u00a0https:\/\/doi.org\/10.1016\/j.chroma.2019.04.015<\/a><\/p>\n

If you have any questions or comments or if you see potential how our methods and insights can be helpful in your projects, please do not hesitate to contact us: info@rades-development.com or +49-40-57004180[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
POSTER AWARD AT ANNUAL MEETING OF THE SOCIETY FOR DERMOPHARMACY<\/span><\/div>\n

[\/vc_column_text][vc_column_text]\"\"<\/p>\n

Julia Puschmann of RaDes GmbH was awarded the first prize of the “Hans Christan Korting-Nachwuchspreis f\u00fcr Dermopharmazie” at the annual conference of the Society for Dermopharmacy and had the opportunity to present her work in two short talks. We congratulate Julia on her award!<\/p>\n

She received it for her poster entitled “How does the emulsifier concentration affect API stability in emulsion gels and skin penetration?\u201d. It demonstrates that it is possible to stabilize hydrolysis-prone actives in aqueous creams if the active is lipophilic and you use the right formulation technology! Using the active betamethasone dipropionate, she elucidated the underlying mechanisms, such as the influence of emulsifier concentration and the correlation of degradation with increasing free drug concentration in the aqueous phase.<\/p>\n

In addition, she demonstrated that the skin penetration, tested on the pig ear with the Hamburg model (https:\/\/doi.org\/10.1016\/j.ejpb.2015.03.030), was further influenced by a changed saturation of the formulation upon addition of co-solvents.<\/p>\n

Meanwhile, her corresponding paper was also published: (https:\/\/doi.org\/10.1016\/j.ijpharm.2019.02.044).<\/p>\n

If you have any questions or comments, don\u2019t hesitate to contact us: info@rades-development.com<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
RaDes presents at \u201eAPV Expert Workshop: Emulsions\u201c<\/span><\/div>\n

[\/vc_column_text][vc_column_text]Emulsions are important systems in drug delivery, especially for topical application, \"\"<\/a>but also orally and parenterally. The APV workshop on 01 to 02 April 2019 will provide a comprehensive insight, including formulation, characterization and processes.<\/p>\n

Michael Herbig of RaDes will give a presentation on: \u201dCream 2.0\u201c – Enhancing scope, performance and robustness of emulsions through rational design\u201d. He is presenting new insights in distribution phenomena in emulsions and their effects on stability and performance, on effects of emulsifiers, consistency adjusting systems and approaches to modify skin penetration.<\/p>\n

Find the program details here: https:\/\/www.apv-mainz.de\/fileadmin\/dateiablage\/apv-mainz\/Seminare\/oeffentllich\/6767_Emulsions_experts.pdf<\/a><\/p>\n

If you\u2019re interested in further information, don\u2019t hesitate to contact us: info@rades-development.com<\/a>.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
Rheometer for formulation characterization implemented<\/span><\/span><\/div>\n

[\/vc_column_text][vc_column_text]\"\"<\/p>\n

With the implementation of the rheometer MCR 102 by Anton Paar GmbH we have added a new tool for formulation characterization to our equipment list. With this instrument we can perform both oscillatory and rotational measurements of semisolids and liquids. By variation of the chosen system (plate\/plate, cone\/plate, cylinder\/beaker) we can obtain information on structure and behavior under stress of different formulation types.<\/p>\n

Oscillation rheology allows prognosis for long-term stability and behavior under stress e.g. pumping into the storage vessel. Additionally, the influence of stress on the formulation can be measured. Using special methods, also the recovery of the structure after stress application can be shown. Does the formulation reach its structure before the stress\u00a0 application or is the formulation changed due to the destruction of the inner structure? Furthermore, the impact of varying concentrations, batches and suppliers of excipients can be compared to collect data on critical quality attributes e.g. the behavior under thermal stress.<\/p>\n

Various formulations regarding type (emulsions, creams, ointments etc.), excipients (critical quality attributes) and storage conditions can be compared to evaluate the best possible prototype for your development and to support the trouble shooting of existing products.<\/p>\n

If you have any questions, don\u2019t hesitate to contact us: info@rades-development.com<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner row_inner_height_percent=”0″ back_color=”color-xsdn” overlay_alpha=”50″ gutter_size=”3″ shift_y=”0″ z_index=”0″ el_class=”rades-news-row-first”][vc_column_inner column_width_percent=”100″ gutter_size=”3″ override_padding=”yes” column_padding=”2″ overlay_alpha=”50″ shift_x=”0″ shift_y=”0″ shift_y_down=”0″ z_index=”0″ medium_width=”0″ mobile_width=”0″ width=”1\/1″][vc_column_text el_class=”rades-main-headline”]<\/p>\n

<\/div>\n
Waters Acquity\u2122 UPLC\u2122 H-Class PLUS implemented<\/span><\/div>\n

[\/vc_column_text][vc_column_text]\"\"<\/p>\n

Since end of October, a Waters ACQUITY\u2122 UPLC\u2122 H-Class PLUS with PDA e\u03bb (UV\/VIS) & QDa (single mass spectrometer) detectors expands the analytical equipment at RaDes GmbH.<\/p>\n

We can cover a broad range of customer needs – from method development using Quality by Design, the transfer of analytical methods between HPLC and UPLC\u2122 technology, up to the fast and reliable analysis of a large sample size.<\/p>\n

What do these detectors stand for?<\/strong><\/p>\n

PDA e\u03bb:<\/strong> highly sensitive photodiode array UV\/VIS detector with an extended wavelength range between 190\u00a0nm to 800 nm to receive spectral information up to the visible range (e.g. to investigate discolorations) and for a robust quantification of compounds over a wide linear range.<\/p>\n

QDa:<\/strong> Mass spectrometer (size of a UV\/VIS detector) for peak tracking, quantification of compounds at a low concentration level or with a low UV absorption, assessment of co-elution.<\/p>\n

The system contains next a solvent selection valve (six additional solvents) a column manager (four columns) to significantly save time and resources during method development.<\/p>\n

All our HPLC and UPLC\u2122 instruments are connected to the latest version of Empower\u2122 3 (Service Release 3) of Waters GmbH to ensure high-quality data management.<\/p>\n

Particular benefits for our customers include:<\/strong><\/p>\n

1) Analysis of poor UV-absorbing molecules such as macrolides and peptides – a trend in dermatology.
\n2) Analysis of low dose formulations – another trend in dermatology.
\n3) Faster and better method development for classical HPLC:<\/p>\n